Abstract
Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Benzoquinones / chemistry
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Benzoquinones / isolation & purification*
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Benzoquinones / pharmacology
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Cordia / chemistry*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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HL-60 Cells
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Humans
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Molecular Structure
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Piperidones / chemistry
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Piperidones / isolation & purification*
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Piperidones / pharmacology
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Plants, Medicinal / chemistry*
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Superoxides / metabolism
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Tetradecanoylphorbol Acetate / pharmacology
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Thailand
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Xanthine Oxidase / drug effects
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Xanthine Oxidase / metabolism
Substances
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Alkaloids
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Benzoquinones
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Free Radical Scavengers
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Piperidones
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Terpenes
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cordiarimide A
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cordiarimide B
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globiferane
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Superoxides
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quinone
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Xanthine Oxidase
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Tetradecanoylphorbol Acetate